Meg Ryan’s warmth and unmistakable charm made her a defining presence in late 20th-century American film. In Innerspace (1987), she played Lisa, the feisty girlfriend caught up in a wild sci-fi adventure directed by Joe Dante, hinting at the blend of humor and heart that would become her trademark. Fans might also recognize her from City of Angels, where she portrayed Maggie, a compassionate heart surgeon entangled in a bittersweet romance with an angel played by Nicolas Cage. Ryan’s ability to balance vulnerability and spunk shines in these roles, especially in romantic comedies like When Harry Met Sally, where her performance as Sally Albright created one of cinema’s most memorable moments. She carved out a niche pairing relatable characters with memorable dialogue, helping define the romantic comedy genre in the 1990s and making her more than just a screen presence but a symbol of the era’s heartfelt storytelling.